Dessent, Caroline Elizabeth Helen orcid.org/0000-0003-4944-0413, Cercola, Rosaria, Wong, Natalie et al. (6 more authors) (2020) Direct Measurement of the Visible to UV Photodissociation Processes for the PhotoCORM TryptoCORM. Chemistry : A European Journal. ISSN 1521-3765
Abstract
PhotoCORMs are light‐triggered compounds that release CO for medical applications. Here, we apply laser spectroscopy in the gas phase to TryptoCORM, a known photoCORM that has been shown to destroy Escherichia coli upon visible‐light activation. Our experiments allow us to map TryptoCORM’s photochemistry across a wide wavelength range by using novel laser‐interfaced mass spectrometry (LIMS). LIMS provides the intrinsic absorption spectrum of the photoCORM along with the production spectra of all of its ionic photoproducts for the first time. Importantly, the photoproduct spectra directly reveal the optimum wavelengths for maximizing CO ejection, and the extent to which CO ejection is compromised at redder wavelengths. A series of comparative studies were performed on TryptoCORM‐CH3CN which exists in dynamic equilibrium with TryptoCORM in solution. Our measurements allow us to conclude that the presence of the labile CH3CN facilitates CO release over a wider wavelength range. This work demonstrates the potential of LIMS as a new methodology for assessing active agent release ( e.g. CO, NO, H2S) from light‐activated prodrugs.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Keywords: | CORM,PhotoCORM,Laser Photochemistry,Antimicrobial,transition metal complexes |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 01 May 2020 09:40 |
Last Modified: | 07 Feb 2025 00:27 |
Published Version: | https://doi.org/10.1002/chem.202001077 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1002/chem.202001077 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:160106 |