Valverde, Pablo, Vendeville, Jean-Baptiste, Hollingsworth, Kristian et al. (13 more authors) (2020) Chemoenzymatic synthesis of 3-deoxy-3-fluoro-L-fucose and its enzymatic incorporation into glycoconjugates. Chemical Communications. ISSN 1364-548X
Abstract
The first synthesis of 3-deoxy-3-fluoro-l-fucose is presented, which employs a d- to l-sugar translation strategy, and involves an enzymatic oxidation of 3-deoxy-3-fluoro-l-fucitol. Enzymatic activation (FKP) and glycosylation using an -1,2 and an -1,3 fucosyltransferase to obtain two fluorinated trisaccharides demonstrates its potential as a novel versatile chemical probe in glycobiology.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number EPSRC EP/S013741/1 |
Depositing User: | Pure (York) |
Date Deposited: | 04 May 2020 11:50 |
Last Modified: | 13 Feb 2025 05:27 |
Published Version: | https://doi.org/10.1039/D0CC02209H |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1039/D0CC02209H |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:160069 |