Ulamec, SM and Radford, SE orcid.org/0000-0002-3079-8039 (2020) Spot the Difference: Function versus Toxicity in Amyloid Fibrils. Trends in Biochemical Sciences. ISSN 0968-0004
Abstract
In a recent study, Hervas et al. extracted Orb2 fibrils, that are involved in long-term memory formation, from Drosophila brains, characterised their function, and determined their structure using cryo-electron microscopy (cryo-EM). The fibrils show a remarkable resemblance to amyloid β (Aβ) fibrils associated with Alzheimer’s disease, highlighting the subtle difference between functional and dysfunctional amyloid.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2020 Elsevier Ltd. This is an author produced version of a paper published in Trends in Biochemical Sciences. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | amyloid; cryo-electron microscopy; Orb2; CPEB; Alzheimer; memory |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Structural Molecular Biology (Leeds) |
Funding Information: | Funder Grant number Wellcome Trust 204963/Z/16/Z |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Apr 2020 10:50 |
Last Modified: | 03 May 2021 00:38 |
Status: | Published online |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.tibs.2020.04.007 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:159758 |