Gillespie, A.M., Liyim, D., Goepel, J.R. et al. (2 more authors) (2000) Placental site trophoblastic tumour : a rare but potentially curable cancer. British Journal of Cancer, 82 (6). pp. 1186-1190. ISSN 0007-0920
Abstract
Placental site trophoblastic tumour (PSTT) is a rare form of gestational trophoblastic disease (GTD). We have conducted an analysis of all cases of PSTT managed at the Trophoblastic Disease Screening and Treatment Centre, Sheffield, from 1984 to 1996. During this time we received 4,988 registrations for GTD and managed seven cases of PSTT. A large range of interval between antecedent pregnancy and presentation was observed - the most common presenting symptoms being irregular vaginal bleeding with or without preceding amenorrhoea. Three out of seven patients had disease confined to the uterus at diagnosis and were successfully treated by hysterectomy alone. Two out of seven patients had pulmonary metastases in addition to uterine tumour and were treated with combination chemotherapy--both are alive and well. Of the remaining two patients one had distant and the other loco-regional metastases and both died despite numerous therapeutic interventions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2000 Cancer Research Campaign. |
Keywords: | Adult; Combined Modality Therapy; Female; Humans; Hysterectomy; Middle Aged; Pregnancy; Prognosis; Retrospective Studies; Treatment Outcome; Trophoblastic Tumor, Placental Site; Uterine Neoplasms |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 17 Apr 2020 10:07 |
Last Modified: | 17 Apr 2020 10:07 |
Status: | Published |
Publisher: | Springer Nature |
Refereed: | Yes |
Identification Number: | 10.1054/bjoc.1999.1061 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:159612 |