Day, Harriet L L, Suwansawang, Sopapun, Halliday, David M orcid.org/0000-0001-9957-0983 et al. (1 more author) (2020) Sex differences in auditory fear discrimination are associated with altered medial prefrontal cortex function. Scientific Reports. 6300. ISSN 2045-2322
Abstract
The increased prevalence of post-traumatic stress disorder (PTSD) that is observed in women may involve sex differences in learned fear inhibition and medial prefrontal cortex (mPFC) function. PTSD is characterized by fear overgeneralization involving impaired fear regulation by safety signals. We recently found that males show fear discrimination and females show fear generalization involving reduced safety signalling after extended fear discrimination training. Here we determined if these sex differences involve altered mPFC function. Male and female rats underwent three days of auditory fear discrimination training, where one tone (CS+) was paired with footshock and another tone (CS-) was presented alone. Local field potentials were recorded from prelimbic (PL) and infralimbic (IL) mPFC during retrieval. We found that males discriminated and females generalized based on cue-induced freezing at retrieval. This was accompanied by sex differences in basal theta and gamma oscillations in PL and IL. Importantly, males also showed PL/IL theta activation during safety signalling by the CS- and IL gamma activation in response to the threat-related CS+, both of which were absent in females. These results add to growing evidence indicating that sex differences in learned fear inhibition are associated with altered mPFC function.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2020 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Electronic Engineering (York) |
Depositing User: | Pure (York) |
Date Deposited: | 16 Apr 2020 12:10 |
Last Modified: | 16 Oct 2024 16:33 |
Published Version: | https://doi.org/10.1038/s41598-020-63405-w |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1038/s41598-020-63405-w |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:159588 |