Comans, T.A., Nguyen, K.-H., Ratcliffe, J. et al. (2 more authors) (2020) Valuing the AD-5D dementia utility instrument : an estimation of a general population tariff. PharmacoEconomics, 38 (8). pp. 871-881. ISSN 1170-7690
Abstract
Objective This paper reports on the valuation of quality-of-life states in the Alzheimer’s Disease Five Dimensions (AD-5D) instrument in a representative sample of the general population in Australia using the discrete-choice experiment with duration (DCETTO) elicitation technique.
Method A DCE with 200 choice sets of two quality-of-life (QoL) state–duration combinations blocked into 20 survey versions, with ten choice sets in each version, was designed and administered online to a sample representative of the Australian population. Two additional choice sets comprising internal consistency and dominance checks were included in each survey version. A range of model specifications investigating preferences with respect to duration and interactions between AD-5D dimension levels were estimated. Utility weights were developed, with estimated coefficients transformed to the 0 (being dead) to 1 (full health) scale, suitable for the calculation of quality-adjusted life-year (QALY) weights for use in economic evaluation.
Results In total, 1999 respondents completed the choice experiment. Overall, respondents were slightly better educated and had higher annual incomes than the Australian general population. The estimation results from different specifications and models were broadly consistent with the monotonic nature of the AD-5D: utility increased with increased life expectancy and decreased as the severity level for each dimension worsened. A utility value set was generated for the calculation of utilities for all QoL states defined by the AD-5D descriptive system.
Conclusion The DCE-based utility value set is now available to use to generate QALYs for the economic evaluation of treatments and interventions targeting people with dementia and/or their family caregivers.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Springer Nature Switzerland AG. This is an author-produced version of a paper subsequently published in PharmacoEconomics. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | dementia; utility weight; preference; quality adjusted life year; discrete choice experiment; health economics; economic evaluation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 29 Apr 2020 10:44 |
Last Modified: | 11 May 2021 12:39 |
Status: | Published |
Publisher: | Springer Nature |
Refereed: | Yes |
Identification Number: | 10.1007/s40273-020-00913-7 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:159553 |