El-Khamisy, S.F. orcid.org/0000-0003-2721-7763 (2011) To live or to die: a matter of processing damaged DNA termini in neurons. EMBO Molecular Medicine, 3 (2). pp. 78-88. ISSN 1757-4676
Abstract
Defects in the repair of deoxyribonucleic acid (DNA) damage underpin several hereditary neurological diseases in humans. Of the different activities that repair chromosomal DNA breaks, defects in resolving damaged DNA termini are among the most common causes of neuronal cell death. Here, the molecular mechanisms of some of the DNA end processing activities are reviewed and the association with human neurodegenerative disease is discussed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2011 EMBO Molecular Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | aprataxin; DNA repair; neuron; TDP1; topoisomerase |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield) |
Funding Information: | Funder Grant number WELLCOME TRUST (THE) 091043/B/09/Z WELLCOME TRUST (THE) 085284/B/08/Z |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 15 Apr 2020 09:40 |
Last Modified: | 15 Apr 2020 09:47 |
Status: | Published |
Publisher: | Wiley Open Access |
Refereed: | Yes |
Identification Number: | 10.1002/emmm.201000114 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:159494 |
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