Giovannini, Giorgia, Kunc, Filip, Piras, Carmen C. orcid.org/0000-0002-7128-2979 et al. (4 more authors) (2017) Stabilizing silica nanoparticles in hydrogels:impact on storage and polydispersity. RSC Advances. pp. 19924-19933. ISSN 2046-2069
Abstract
For successful nanomedicine, it is important that the unique, size-dependent physico-chemical properties of the nanomaterial remain predictably constant during both the storage and the manipulation of the material. Here a novel approach to preserve the colloidal stability and degradation of NPs is described. The concept is simple: (a) a solution of monodisperse particles is formulated into a responsive water- or PBS-based hydrogel; (b) the gel can be reversibly turned into a solution after long term storage by shaking it by hand; (c) the NP can be diluted and used in any desired application without the need for excessive manipulation. The differences between the physico-chemical properties of NPs stored in solution and in gel are compared. Two types of NPs were involved in this study: silica NPs of ∼100 nm and Au-NPs of 30 and 80 nm in diameter. The key findings are: the fibrous matrix of the hydrogel limits the NP mobility, significantly reduces NP aggregation and conserves the NP morphology; both the hydrogelator and the NPs show negligible toxicity towards the model U937 human hematopoietic cell line; undesired leaching of cargo material loaded inside the particles is reduced, which could be an important feature for drug delivery systems.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2017 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 14 Apr 2020 16:20 |
Last Modified: | 16 Oct 2024 16:32 |
Published Version: | https://doi.org/10.1039/C7RA02427D |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/C7RA02427D |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:159483 |