Waller, R. orcid.org/0000-0001-5815-8829, Mandeya, M., Viney, E. et al. (2 more authors) (2020) Histological characterization of interneurons in Alzheimer's disease reveals a loss of somatostatin interneurons in the temporal cortex. Neuropathology, 40 (4). pp. 336-346. ISSN 0919-6544
Abstract
Neuronal dysfunction and synaptic loss are major hallmarks of Alzheimer's disease (AD) which correlate with symptom severity. Impairment of the γ‐aminobutyric acid (GABA)ergic inhibitory interneurons, which form around 20% of the total neuronal network, may be an early event contributing to neuronal circuit dysfunction in neurodegenerative diseases. This study examined the expression of two of the main classes of inhibitory interneurons, parvalbumin (PV) and somatostatin (SST) interneurons in the temporal cortex and hippocampus of AD and control cases, using immunohistochemistry. We report a significant regional variation in the number of PV and SST interneurons with a higher number identified per mm2 in the temporal cortex compared to the hippocampus. Fewer SST interneurons, but not PV interneurons, were identified per mm2 in the temporal cortex of AD cases compared to control subjects. Our results support regional neuroanatomical effects on selective interneuron classes in AD, and suggest that impairment of the interneuronal circuit may contribute to neuronal dysfunction and cognitive decline in AD.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2020 Japanese Society of Neuropathology. This is an author-produced version of a paper subsequently published in Neuropathology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Alzheimer disease; humans; interneurons; pathology; somatostatin |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number ALZHEIMER'S SOCIETY 242 (AS-PG-14-015) ALZHEIMER'S SOCIETY AS-PG-17-007 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Apr 2020 13:17 |
Last Modified: | 25 Nov 2021 14:06 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/neup.12649 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:159357 |