Amadi-Kamalu, Chidi, Clarke, Holly, McRobie, Matthew et al. (8 more authors) (2020) Investigation of Parameters that Affect Resin Swelling in Green Solvents. ChemistryOpen. pp. 431-441.
Abstract
The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020, The Author(s). |
Keywords: | ChemMatrix,peptide,polystyrene,solvent,swelling |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 07 Apr 2020 15:50 |
Last Modified: | 16 Oct 2024 16:31 |
Published Version: | https://doi.org/10.1002/open.202000030 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/open.202000030 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:159310 |