Chidwick, Harriet and Fascione, Martin Anthony orcid.org/0000-0002-0066-4419 (2019) Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac). Organic and Biomolecular Chemistry. pp. 799-809. ISSN 1477-0539
Abstract
The non-mammalian nonulosonic acid sugar pseudaminic acid (Pse) is present on the surface of a number of human pathogens including Campylobacter jejuni and Helicobacter pylori and other bacteria such as multidrug resistant Acinetobacter baumannii. It is likely important for evasion of the host immune sysyem, and also plays a role in bacterial motility through flagellin glycosylation. Herein we review the mechanistic and structural characterisation of the enzymes responsible for the biosynthesis of the Pse parent structure, Pse5Ac7Ac in bacteria.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Royal Society of Chemistry 2020. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 07 Apr 2020 15:30 |
Last Modified: | 29 Dec 2024 00:11 |
Published Version: | https://doi.org/10.1039/C9OB02433F |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1039/C9OB02433F |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:159297 |
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