Kaye, Paul M orcid.org/0000-0002-8796-4755, Cruz, Israel, Picado, Albert et al. (2 more authors) (2020) Leishmaniasis immunopathology-impact on design and use of vaccines, diagnostics and drugs. Seminars in immunopathology. pp. 1-18. ISSN 1863-2300
Abstract
Leishmaniasis is a disease complex caused by 20 species of protozoan parasites belonging to the genus Leishmania. In humans, it has two main clinical forms, visceral leishmaniasis (VL) and cutaneous or tegumentary leishmaniasis (CL), as well as several other cutaneous manifestations in a minority of cases. In the mammalian host Leishmania parasites infect different populations of macrophages where they multiply and survive in the phagolysosomal compartment. The progression of both VL and CL depends on the maintenance of a parasite-specific immunosuppressive state based around this host macrophage infection. The complexity and variation of immune responses and immunopathology in humans and the different host interactions of the different Leishmania species has an impact upon the effectiveness of vaccines, diagnostics and drugs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Springer Nature Switzerland AG. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Hull York Medical School (York) The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 07 Apr 2020 09:40 |
Last Modified: | 16 Oct 2024 16:30 |
Published Version: | https://doi.org/10.1007/s00281-020-00788-y |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1007/s00281-020-00788-y |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:159211 |
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