Koychev, I., Vaci, N. orcid.org/0000-0002-8094-0902, Bilgel, M. et al. (7 more authors) (2020) Prediction of rapid amyloid and phospotylated‐Tau accumulation in cognitively healthy individuals. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 12 (1). e12019. ISSN 2352-8729
Abstract
Objective
To test the hypothesis that among cognitively healthy individuals, distinct groups exist in terms of amyloid and phosphorylated‐tau accumulation rates; that if rapid accumulator groups exist, their membership can be predicted by Alzheimer's disease (AD) risk factors, and that time points of significant increase in AD protein accumulation will be evident.
Methods
The analysis reports data from 263 individuals from the BIOCARD and 184 individuals from the Baltimore Longitudinal Study of Aging with repeated cerebrospinal fluid (CSF) and positron emission tomography (PET) sampling, respectively. We used latent class mixed‐effect models to identify distinct classes of amyloid (CSF and PET) and p‐Tau (CSF) accumulation rates and generalized additive modeling to investigate non‐linear changes to AD biomarkers.
Results
For both amyloid and p‐Tau latent class models we confirmed the existence of two separate classes: accumulators and non‐accumulators. The accumulator and non‐accumulator groups differed significantly in terms of baseline AD protein levels and slope of change. APOE ε4 carrier status and episodic memory predicted amyloid class membership. Non‐linear models revealed time points of significant increase in the rate of amyloid and p‐Tau accumulation whereby APOE ε4 carrier status associated with earlier age at onset of rapid accumulation.
Conclusions
The current analysis demonstrates the existence of distinct classes of amyloid and p‐Tau accumulators. Predictors of class membership were identified but the overall accuracy of the models was modest, highlighting the need for additional biomarkers that are sensitive to early disease phenotypes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 the Alzheimer's Association. |
Keywords: | amyloid; CSF; emerging Alzheimer's disease pathology; positron emission tomography; phosphorylated tau |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 03 Apr 2020 09:56 |
Last Modified: | 25 Jun 2023 22:13 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/dad2.12019 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:159119 |