McFarlane, Emma, Mokgethi, Thabang, Kaye, Paul M orcid.org/0000-0002-8796-4755 et al. (4 more authors) (2019) IL-4 Mediated Resistance of BALB/c Mice to Visceral Leishmaniasis Is Independent of IL-4Rα Signaling via T Cells. Frontiers in immunology. 1957. ISSN 1664-3224
Abstract
Previous studies infecting global IL-4Rα-/-, IL-4-/-, and IL-13-/-mice on a BALB/c background with the visceralizing parasite Leishmania donovani have shown that the T helper 2 cytokines, IL-4, and IL-13, play influential but not completely overlapping roles in controlling primary infection. Subsequently, using macrophage/neutrophil-specific IL-4Rα deficient BALB/c mice, we demonstrated that macrophage/neutrophil unresponsiveness to IL-4 and IL-13 did not have a detrimental effect during L. donovani infection. Here we expand on these findings and show that CD4+ T cell-(Lckcre), as well as pan T cell-(iLckcre) specific IL-4Rα deficient mice, on a BALB/c background, unlike global IL-4Rα deficient mice, are also not adversely affected in terms of resistance to primary infection with L. donovani. Our analysis suggested only a transient and tissue specific impact on disease course due to lack of IL-4Rα on T cells, limited to a reduced hepatic parasite burden at day 30 post-infection. Consequently, the protective role(s) demonstrated for IL-4 and IL-13 during L. donovani infection are mediated by IL-4Rα-responsive cell(s) other than macrophages, neutrophils and T cells.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 McFarlane, Mokgethi, Kaye, Hurdayal, Brombacher, Alexander and Carter. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | Pure (York) |
Date Deposited: | 30 Mar 2020 08:30 |
Last Modified: | 05 Jan 2025 00:25 |
Published Version: | https://doi.org/10.3389/fimmu.2019.01957 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.3389/fimmu.2019.01957 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:158887 |