Spicer, Christopher D. orcid.org/0000-0001-8787-578X, Pujari-Palmer, Michael, Autefage, Hélène et al. (4 more authors) (2020) Synthesis of Phospho-Amino Acid Analogues as Tissue Adhesive Cement Additives. ACS Central Science. pp. 226-231. ISSN 2374-7943
Abstract
In this paper we report the synthesis of a library of phospho-amino acid analogues, via a novel single-step allyl-phosphoester protection/Pd-mediated deprotection strategy. These phosphoserine and phosphotyrosine analogues were then applied as additives to create adhesive calcium phosphate cements, allowing us to probe the chemical origins of the increased surface binding strength. We demonstrate the importance of multiple calcium binding motifs in mediating adhesion, as well as highlighting the crucial role played by substrate hydrophobicity and orientation in controlling binding strength.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 American Chemical Society. This is an open access article published under an ACS Author Choice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 11 Mar 2020 09:20 |
Last Modified: | 13 Nov 2024 09:13 |
Published Version: | https://doi.org/10.1021/acscentsci.9b01149 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/acscentsci.9b01149 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:158316 |
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Description: Synthesis of Phospho-Amino Acid Analogues as Tissue Adhesive Cement Additives