Colman, MA orcid.org/0000-0003-2817-8508, Holmes, M, Whittaker, DG et al. (2 more authors) (2020) Multi-scale approaches for the simulation of cardiac electrophysiology: I - sub-cellular and stochastic calcium dynamics from cell to organ. Methods. ISSN 1046-2023
Abstract
Computational models of the heart at multiple spatial scales, from sub-cellular nanodomains to the whole-organ, are a powerful tool for the simulation of cardiac electrophysiology. Application of these models has provided remarkable insight into the normal and pathological functioning of the heart. In these two articles, we present methods for modelling cardiac electrophysiology at all of these spatial scales. In part one, presented here, we discuss methods and approaches for modelling sub-cellular calcium dynamics at the whole-cell and organ scales, valuable for modelling excitation-contraction coupling and mechanisms of arrhythmia triggers.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Elsevier Inc. All rights reserved. This is an author produced version of a paper published in Methods. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | calcium handling; excitation-contraction coupling; spontaneous activity; cardiac tissue; electrophysiology; action potential; propagation; computational modelling |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Funding Information: | Funder Grant number MRC (Medical Research Council) MR/M014967/1 British Heart Foundation PG/16/74/32374 |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 Mar 2020 14:00 |
Last Modified: | 01 Mar 2021 01:38 |
Status: | Published online |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ymeth.2020.02.011 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:157959 |
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