Single cell deformation in shear and inertia dominant flow regimes

Armistead, FJ orcid.org/0000-0003-1274-5379, De Pablo, JG, Gadêlha, H et al. (2 more authors) (2017) Single cell deformation in shear and inertia dominant flow regimes. In: Proceedings of the 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2017: 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, 22-26 Oct 2017, Savannah, Georgia, USA. Chemical and Biological Microsystems Society , pp. 838-839. ISBN 978-0-692-94183-6

Abstract

We report new insight into cell deformability in inertia-dominant and shear-dominant flows. As a first model, we show that the deformability of HL60 cells changes with flow regime, which shows that flow regime can be used to probe different aspects of a cell’s internal structure. Additionally, we show the importance of flow regime when using deformability to distinguish between primary (SW480) and secondary (SW620) colorectal cancer cell lines.

Metadata

Item Type:	Proceedings Paper
Authors/Creators:	Armistead, FJ https://orcid.org/0000-0003-1274-5379 De Pablo, JG Gadêlha, H Peyman, SA Evans, SD https://orcid.org/0000-0001-8342-5335
Keywords:	Single cells, deformability, cell mechanics, shear-flow, inertial-flow
Dates:	Published: 22 October 2017
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) > Molecular & Nanoscale Physics
Funding Information:	Funder Grant number MRC (Medical Research Council) MR/M009084/1
Depositing User:	Symplectic Publications
Date Deposited:	03 Mar 2020 15:11
Last Modified:	03 Mar 2020 15:11
Published Version:	https://cbmsociety.org/microtas/microtas_proceedin...
Status:	Published
Publisher:	Chemical and Biological Microsystems Society
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:157918

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Single cell deformation in shear and inertia dominant flow regimes

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