Gurdasani, D., Iles, L. orcid.org/0000-0003-4113-5844, Dillon, D.G. et al. (10 more authors) (2014) A systematic review of definitions of extreme phenotypes of HIV control and progression. AIDS, 28 (2). pp. 149-162. ISSN 0269-9370
Abstract
The study of individuals at opposite ends of the HIV clinical spectrum can provide invaluable insights into HIV biology. Heterogeneity in criteria used to define these individuals can introduce inconsistencies in results from research and make it difficult to identify biological mechanisms underlying these phenotypes. In this systematic review, we formally quantified the heterogeneity in definitions used for terms referring to extreme phenotypes in the literature, and identified common definitions and components used to describe these phenotypes. We assessed 714 definitions of HIV extreme phenotypes in 501 eligible studies published between 1 January 2000 and 15 March 2012, and identified substantial variation among these. This heterogeneity in definitions may represent important differences in biological endophenotypes and clinical progression profiles of individuals selected by these, suggesting the need for harmonized definitions. In this context, we were able to identify common components in existing definitions that may provide a framework for developing consensus definitions for these phenotypes in HIV infection.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 Wolters Kluwer Health / Lippincott Williams & Wilkins. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivitives 3.0 License, (https://creativecommons.org/licenses/by-nc-nd/3.0/) where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
Keywords: | definitions; elite controllers; extreme-trait designs; HIV; HIV controllers; long-term nonprogressors; phenotypes; slow progressors; systematic review; viremic controllers |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Arts and Humanities (Sheffield) > Department of Archaeology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 03 Mar 2020 16:14 |
Last Modified: | 03 Mar 2020 16:14 |
Status: | Published |
Publisher: | Lippincott, Williams & Wilkins |
Refereed: | Yes |
Identification Number: | 10.1097/QAD.0000000000000049 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:157866 |
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