Holden, AV, Begg, GA, Bounford, K et al. (2 more authors) (2019) Phase entrainment of induced ventricular fibrillation: A human feasibility and proof of concept study. Journal of Atrial Fibrillation, 12 (4). ISSN 1941-6911
Abstract
Cardioversion and defibrillation by a single high energy shock applied by myocardial or body surface electrodes is painful, causes long term tissue damage, and is associated with worsening long term outcomes, but is almost always required for treatment of ventricular fibrillation .
As a initial step towards developing methods that can terminate ventricular arrhythmias painlessly, we aim to determine if pacing stimuli at a rate of 5/s applied via an implantable cardiac defibrillator (ICD) can modify human ventricular fibrillation. In 8 patients undergoing defibrillation testing of a new/exchanged intracardiac defibrillator, five seconds of pacing at five stimuli per second was applied during the 10-20 seconds of induced ventricular fibrillation before the defibrillation shock was automatically applied, and the cardiac electrograms recorded and analyzed.
The high frequency pacing did not entrain the ventricular fibrillation, but altered the dominant frequency in all 8 patients, and modulated the phase computed via the Hilbert Transform, in four of the patients.
In this pilot study we demonstrate that high frequency pacing applied via ICD electrodes during VF can alter the dominant frequency and modulate the probability density of the phase of the electrogram of the ventricular fibrillation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This article is protected by copyright. This is an open access article under the terms of the Creative Commons Attribution License. |
Keywords: | Ventricular fibrillation, Implantable cardioverter defibrillator, High frequency pacing, Anti-tachycardia pacing |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Feb 2020 16:33 |
Last Modified: | 25 Jun 2023 22:10 |
Published Version: | http://www.jafib.com/published.php?type=full&id=22... |
Status: | Published |
Publisher: | CardioFront |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:157606 |