Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation

Abstract

Background

Using cardiovascular magnetic resonance imaging (CMR), it is possible to detect diffuse fibrosis of the left ventricle (LV) in patients with atrial fibrillation (AF), which may be independently associated with recurrence of AF after ablation. By conducting CMR, clinical, electrophysiology and biomarker assessment we planned to investigate LV myocardial fibrosis in patients undergoing AF ablation.

Methods

LV fibrosis was assessed by T1 mapping in 31 patients undergoing percutaneous ablation for AF. Galectin-3, coronary sinus type I collagen C terminal telopeptide (ICTP), and type III procollagen N terminal peptide were measured with ELISA. Comparison was made between groups above and below the median for LV extracellular volume fraction (ECV), followed by regression analysis.

Results

On linear regression analysis LV ECV had significant associations with invasive left atrial pressure (Beta 0.49, P = 0.008) and coronary sinus ICTP (Beta 0.75, P < 0.001), which remained significant on multivariable regression.

Conclusion

LV fibrosis in patients with AF is associated with left atrial pressure and invasively measured levels of ICTP turnover biomarker.

Metadata

Item Type:	Article
Authors/Creators:	Begg, GA https://orcid.org/0000-0001-5260-4293 Swoboda, PP Karim, R Oesterlein, T Rhode, K Holden, AV Greenwood, JP https://orcid.org/0000-0002-2861-0914 Shantsila, E Lip, GYH Plein, S https://orcid.org/0000-0002-0997-4384 Tayebjee, MH
Copyright, Publisher and Additional Information:	© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords:	Atrial fibrillation; Cardiovascular magnetic resonance imaging; Fibrosis; Biomarkers; Voltage mapping
Dates:	Accepted: 15 January 2020 Published (online): 10 February 2020 Published: 10 February 2020
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Biomedical Imaging Science Dept (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	25 Feb 2020 16:39
Last Modified:	25 Jun 2023 22:10
Status:	Published
Publisher:	BMC
Identification Number:	10.1186/s12968-020-0603-y
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:157604

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Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation

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