Saeed, H.K., Sreedharan, S. and Thomas, J.A. orcid.org/0000-0002-8662-7917 (2020) Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics. Chemical Communications, 56 (10). pp. 1464-1480. ISSN 1359-7345
Abstract
This review discusses the advantages of using luminescent d6-transition-metal complexes as cell probes for optical microscopy. In particular it focusses on the Thomas group's use of specific complexes as “building blocks” toward the construction of biomolecular binding substrates, with DNA being a particular target. Using this approach, a range of new imaging probes for conventional optical microscopy, nanoscopy and transmission electron microscopy have been identified. Through selection of specific metal centres and by substitution of coordinated ligands we illustrate how new chemotherapeutics, photo-therapeutics, and theranostics have been identified and developed from the original architectures.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Royal Society of Chemistry. This is an author-produced version of a paper subsequently published in Chemical Communications. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Feb 2020 12:14 |
Last Modified: | 10 Jan 2021 01:38 |
Status: | Published |
Publisher: | Royal Society of Chemistry (RSC) |
Refereed: | Yes |
Identification Number: | 10.1039/c9cc09312e |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:157419 |