Stewart, PM orcid.org/0000-0002-1749-9640 (2019) Modified-Release Hydrocortisone: Is It Time to Change Clinical Practice? Journal of the Endocrine Society, 3 (6). pp. 1150-1153. ISSN 2472-1972
Abstract
The appreciation of the unacceptable outcomes of patients with adrenal insufficiency has brought new developments in glucocorticoid replacement therapy. Efforts have moved beyond simple dose adjustments of the traditional immediate-release hydrocortisone to new formulations of hydrocortisone aimed at mimicking the circadian pattern of physiological glucocorticoid release. The present report has briefly summarized the evidence base behind recent studies that have reported benefits using modified-release preparations and set this in context for today’s clinical practice.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Endocrine Society.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
Keywords: | cortisol; modified-release; adrenal insufficiency; outcomes |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Medicine & Health Faculty Office (Leeds) > Faculty Office Functions (FOMH) (Leeds) > Dean's Office (FOMH) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Feb 2020 13:44 |
Last Modified: | 17 Feb 2020 13:44 |
Status: | Published |
Publisher: | Endocrine Society |
Identification Number: | 10.1210/js.2019-00046 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:157188 |