Bohner, B., Bánsági, T., Tóth, Á. et al. (2 more authors) (2020) Periodic nucleation of calcium phosphate in a stirred biocatalytic reaction. Angewandte Chemie International Edition, 59 (7). pp. 2823-2828. ISSN 1433-7851
Abstract
Highly ordered superstructures composed of inorganic nanoparticles appear in natural and synthetic systems, however the mechanisms of non‐equilibrium self‐organization that may be involved are still poorly understood. Herein, we performed a kinetic investigation of the precipitation of calcium phosphate using a process widely found in microorganisms: the hydrolysis of urea by enzyme urease. With high initial ratio of calcium ion to phosphate, periodic precipitation was obtained accompanied by pH oscillations in a well‐stirred, closed reactor. We propose that an internal pH‐regulated change in the concentration of phosphate ion is the driving force for periodicity. A simple model involving the biocatalytic reaction network coupled with burst nucleation of nanoparticles above a critical supersaturation reproduced key features of the experiments. These findings may provide insight to the self‐organization of nanoparticles in biomineralization and improve design strategies of biomaterials for medical applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | biocatalysis; biomineralization; reaction networks; self-organization; systems chemistry |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Funding Information: | Funder Grant number Engineering and Physical Sciences Research Council EP/K030574/2 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 10 Mar 2020 11:40 |
Last Modified: | 10 Mar 2020 11:40 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/anie.201911213 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:156945 |
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