Alix, J.J.P. orcid.org/0000-0001-8391-9749, McDonough, H.E., Sonbas, B. et al. (6 more authors) (2020) Multi-dimensional electrical impedance myography of the tongue as a potential biomarker for amyotrophic lateral sclerosis. Clinical Neurophysiology, 131 (4). pp. 799-808. ISSN 1388-2457
Abstract
Objective In amyotrophic lateral sclerosis (ALS) bulbar disease biomarkers are lacking. We evaluated a novel tongue electrical impedance myography (EIM) system, utilising both 2D and 3D electrode configurations for detection of tongue pathology.
Methods Longitudinal multi-frequency phase angle spectra were recorded from 41 patients with ALS (baseline, 3 and 6 months) and 30 healthy volunteers (baseline and 6 months). ALS functional rating scale-revised (ALSFRS-R) data and quantitative tongue strength measurements were collected. EIM data were analysed for reliability (intra-class correlation coefficient; ICC) and differences between patients and volunteers ascertained using both univariate (Mann-Whitney U test) and multivariate techniques (feature selection and L2 norm).
Results The device produced highly reliable data (pooled ICC: 0.836). Significant EIM differences were apparent between ALS patients and healthy volunteers (P<0.001). EIM data demonstrated a significant relationship to tongue strength and bulbar ALSFRS-R scores (P<0.015). The EIM recordings revealed a group level longitudinal change over 6 months and consistently identified patients in whom symptoms or tongue strength changed.
Conclusions The novel EIM tongue system produces reliable data and can differentiate between healthy muscle and ALS-related disease.
Significance Tongue EIM utilising multiple frequencies and electrode configurations has potential as a bulbar disease biomarker in ALS.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an author produced version of a paper subsequently published in Clinical Neurophysiology. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Amyotrophic lateral sclerosis; electrical impedance myography; motor neuron |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number MOTOR NEURONE DISEASE ASSOCIATION Alix/Nov16/918-793 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 12 Feb 2020 10:25 |
Last Modified: | 09 Dec 2021 11:26 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.clinph.2019.12.418 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:156873 |