Liptrott, N.J., Giardiello, M. orcid.org/0000-0003-0560-4711, McDonald, T.O. et al. (2 more authors) (2017) Lack of interaction of lopinavir solid drug nanoparticles with cells of the immune system. Nanomedicine, 12 (17). pp. 2043-2054. ISSN 1743-5889
Abstract
Aim: We previously demonstrated that solid drug nanoparticles (SDNs) lopinavir (LPV) dispersed into aqueous media display favorable pharmacokinetics. Methods: The impact of LPV SDNs on the function and phenotype of primary human T cells and macrophages (primary sites of HIV replication) was investigated. Results: LPV significantly increased IL-1β (ninefold higher than untreated cells; p = 0.045) and TNF-α (sixfold higher than untreated cells; p = 0.018) secretion from monocyte-derived macrophages, whereas LPV SDNs did not elicit these responses at comparable drug concentrations. LPV SDNs were demonstrated to be immunologically inert to human T cells and monocyte-derived macrophages. Conclusion: The LPV SDN was demonstrated to exhibit comparable, or favorable behavior compared with an LPV aqueous solution in the employed biocompatibility assessments.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Future Medicine Ltd. This is an author-produced version of a paper subsequently published in Nanomedicine. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | T cells; antiretroviral nanoformulation; immunotoxicology; macrophages; Chemistry, Pharmaceutical; HIV Protease Inhibitors; Humans; Interleukin-1beta; Lopinavir; Macrophages; Materials Testing; Nanoparticles; Particle Size; Polyvinyl Alcohol; Surface Properties; T-Lymphocytes; Tumor Necrosis Factor-alpha |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Materials Science and Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 12 Feb 2020 14:26 |
Last Modified: | 12 Feb 2020 14:26 |
Status: | Published |
Publisher: | Future Medicine |
Refereed: | Yes |
Identification Number: | 10.2217/nnm-2017-0095 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:156865 |