Donnellan, S. and Giardiello, M. orcid.org/0000-0003-0560-4711 (2019) Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis. Journal of Interdisciplinary Nanomedicine, 4 (3). pp. 76-85. ISSN 2058-3273
Abstract
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), causes the most human deaths than any other diseases from a single infectious agent. Treatments are long and costly and have many associated side effects. Intracellular bacilli are slow growing and difficult to target, which is augmenting the emergence of multi‐drug resistance. A hallmark trait of TB is the formation of granulomas, chronic cellular aggregates, which limit bacterial growth but provides a survival reservoir where bacilli may disseminate from. Targeting intracellular Mtb is challenging, but nanomedicine may offer a solution. Nanomedicine is a significantly growing research area and offers the potential for specific disease targeting, dosage reduction, and intracellular drug delivery. This review discusses the application of the various forms of nanomedicine towards targeting of Mtb.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 The Authors Journal of Interdisciplinary Nanomedicine published by British Society for Nanomedicine and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/4.0/) which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | drug targeting; infectious disease; nanomedicine; nanoparticles; tuberculosis |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Materials Science and Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 11 Feb 2020 15:18 |
Last Modified: | 11 Feb 2020 15:26 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/jin2.61 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:156858 |
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