Protein disorder–order interplay to guide the growth of hierarchical mineralized structures

Abstract

A major goal in materials science is to develop bioinspired functional materials based on the precise control of molecular building blocks across length scales. Here we report a protein-mediated mineralization process that takes advantage of disorder–order interplay using elastin-like recombinamers to program organic–inorganic interactions into hierarchically ordered mineralized structures. The materials comprise elongated apatite nanocrystals that are aligned and organized into microscopic prisms, which grow together into spherulite-like structures hundreds of micrometers in diameter that come together to fill macroscopic areas. The structures can be grown over large uneven surfaces and native tissues as acid-resistant membranes or coatings with tuneable hierarchy, stiffness, and hardness. Our study represents a potential strategy for complex materials design that may open opportunities for hard tissue repair and provide insights into the role of molecular disorder in human physiology and pathology.

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Item Type:	Article
Authors/Creators:	Elsharkawy, S Al-Jawad, M Pantano, MF Tejeda-Montes, E Mehta, K Jamal, H Agarwal, S Shuturminska, K Rice, A Tarakina, NV Wilson, RM Bushby, AJ Alonso, M Rodriguez-Cabello, JC Barbieri, E del Río Hernández, A Stevens, MM Pugno, NM Anderson, P Mata, A
Copyright, Publisher and Additional Information:	© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
Dates:	Accepted: 18 April 2018 Published (online): 1 June 2018 Published: December 2018
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	10 Feb 2020 11:28
Last Modified:	10 Feb 2020 11:28
Status:	Published
Publisher:	Nature Research
Identification Number:	10.1038/s41467-018-04319-0
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:156775

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Protein disorder–order interplay to guide the growth of hierarchical mineralized structures

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