Atanasova, Mihaela, Bagdonas, Haroldas and Agirre, Jon orcid.org/0000-0002-1086-0253 (2020) Structural glycobiology in the age of electron cryo-microscopy. CURRENT OPINION IN STRUCTURAL BIOLOGY. pp. 70-78. ISSN 0959-440X
Abstract
The methodology underpinning the construction, refinement, validation and analysis of atomic models of glycoproteins and protein-carbohydrate complexes has received a long-overdue boost in the last five years. This is a very timely development, as the resolution revolution in electron cryo-microscopy is now routinely delivering structures of key glycomedical importance, with a three-dimensional precision where X-ray crystallographic methods have traditionally floundered. This review will focus on the new software developments that have been introduced in the past two years, and their impact on the field of structural glycobiology in terms of published structures.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Elsevier Ltd. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 10 Feb 2020 12:20 |
Last Modified: | 06 Feb 2025 00:09 |
Published Version: | https://doi.org/10.1016/j.sbi.2019.12.003 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.sbi.2019.12.003 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:156757 |