Prospects for Therapies in Osteoarthritis

Abstract

Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients who can use them. New pharmacological therapies for managing OA are required and a number have been developed targeting different tissues in OA: bone and cartilage, synovium and nerves. However, there has been overall limited success. Disease-modifying osteoarthritis drugs (DMOADs) are a putative class of therapies aimed at improving OA structural pathologies and consequent symptoms. Recent DMOAD studies have demonstrated some promising therapies but also provided new considerations for future trials.

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Item Type:	Article
Authors/Creators:	Ghouri, A https://orcid.org/0000-0003-2514-5022 Conaghan, PG https://orcid.org/0000-0002-3478-5665
Copyright, Publisher and Additional Information:	© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords:	Osteoarthritis; Nociceptive pain; DMOAD; Cartilage; Inflammation; Synovitis
Dates:	Accepted: 6 February 2020 Published (online): 13 February 2020 Published: September 2021
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Musculoskeletal Medicine & Imaging (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	12 Feb 2020 13:55
Last Modified:	13 Jan 2023 15:42
Status:	Published
Publisher:	Springer Nature
Identification Number:	10.1007/s00223-020-00672-9
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:156695

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Prospects for Therapies in Osteoarthritis

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