Genetically Determined Height and Risk of Non-hodgkin Lymphoma

Abstract

Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

Metadata

Item Type:	Article
Authors/Creators:	Moore, Amy Kane, Eleanor Victoria https://orcid.org/0000-0002-7438-9982 Wang, Zhaoming Panagiotou, Orestis Teras, Lauren R Monnereau, Alain Wong Doo, Nicole Machiela, Mitchell John Skibola, Christine F. Slager, Susan L. Salles, Gilles Camp, Nicola J Bracci, Paige M. Nieters, Alexandra Vermeulen, Roel C H Vijai, Joseph Smedby, Karin E. Zhang, Yawei Vajdic, Claire M. Cozen, Wendy Spinelli, John J. Hjalgrim, Henrik Giles, Graham G. Link, Brian K Clavel, Jacqueline Arslan, Alan A Purdue, Mark P Tinker, Lesley F Albanes, Demetrius Ferri, Giovanni M Habermann, Thomas M Adami, Hans-Olov Becker, Nikolaus Benavente, Yolanda Bisanzi, Simonetta Boffetta, Paolo Brennan, Paul Brooks-Wilson, Angela R Canzian, Federico Conde, Lucia Cox, David G Curtin, Karen Foretova, Lenka Gapstur, Susan M Ghesquières, Hervé Glenn, Martha Glimelius, Bengt Jackson, Rebecca D Lan, Qing Liebow, Mark Maynadie, Marc McKay, James D Melbye, Mads Miligi, Lucia Milne, Roger L Molina, Thierry Jo Morton, Lindsay M. North, Kari E Offit, Kenneth Padoan, Marina Patel, Alpa V Piro, Sara Ravichandran, Vignesh Riboli, Elio de Sanjose, Silvia Severson, Richard K. Southey, Melissa Caroline Staines, Anthony Stewart, Carolyn Travis, Ruth C. Weiderpass, Elisabete Weinstein, Stephanie Zheng, Tongzhang Chanock, Stephen J. Chatterjee, Nilanjan Rothman, Nathaniel Birmann, Brenda M Cerhan, James R. Berndt, Sonja I
Copyright, Publisher and Additional Information:	© 2020 Moore, Kane, Wang, Panagiotou, Teras, Monnereau, Wong Doo, Machiela, Skibola, Slager, Salles, Camp, Bracci, Nieters, Vermeulen, Vijai, Smedby, Zhang, Vajdic, Cozen, Spinelli, Hjalgrim, Giles, Link, Clavel, Arslan, Purdue, Tinker, Albanes, Ferri, Habermann, Adami, Becker, Benavente, Bisanzi, Boffetta, Brennan, Brooks-Wilson, Canzian, Conde, Cox, Curtin, Foretova, Gapstur, Ghesquières, Glenn, Glimelius, Jackson, Lan, Liebow, Maynadie, McKay, Melbye, Miligi, Milne, Molina, Morton, North, Offit, Padoan, Patel, Piro, Ravichandran, Riboli, de Sanjose, Severson, Southey, Staines, Stewart, Travis, Weiderpass, Weinstein, Zheng, Chanock, Chatterjee, Rothman, Birmann, Cerhan and Berndt. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details
Dates:	Accepted: 19 December 2019 Published: 28 January 2020
Institution:	The University of York
Academic Units:	The University of York > Faculty of Sciences (York) > Health Sciences (York)
Depositing User:	Pure (York)
Date Deposited:	30 Jan 2020 09:30
Last Modified:	09 Apr 2025 23:26
Published Version:	https://doi.org/10.3389/fonc.2019.01539
Status:	Published
Refereed:	Yes
Identification Number:	10.3389/fonc.2019.01539
Related URLs:	https://www.frontiersin.org/articles/10....
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:156251

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Genetically Determined Height and Risk of Non-hodgkin Lymphoma

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