Mitroulis, Ioannis, Ruppova, Klara, Wang, Baomei et al. (25 more authors) (2018) Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. 147-161.e12. ISSN 1097-4172
Abstract
Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of β-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1β and granulocyte-macrophage colony-stimulating factor (GM-CSF), and with adaptations in glucose metabolism and cholesterol biosynthesis. The trained-immunity-related increase in myelopoiesis resulted in a beneficial response to secondary LPS challenge and protection from chemotherapy-induced myelosuppression in mice. Therefore, modulation of myeloid progenitors in the bone marrow is an integral component of trained immunity, which to date, was considered to involve functional changes of mature myeloid cells in the periphery.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved. |
Keywords: | Animals,Cells, Cultured,Granulocyte-Macrophage Colony-Stimulating Factor/metabolism,Immunity, Innate,Immunologic Memory,Interleukin-1beta/metabolism,Male,Mice,Mice, Inbred C57BL,Myeloid Progenitor Cells/drug effects,Myelopoiesis/immunology,beta-Glucans/pharmacology |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | Pure (York) |
Date Deposited: | 22 Jan 2020 13:00 |
Last Modified: | 17 Dec 2024 00:15 |
Published Version: | https://doi.org/10.1016/j.cell.2017.11.034 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.cell.2017.11.034 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:155929 |
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