Chow, S, Green, AI, Arter, C orcid.org/0000-0001-9323-5738 et al. (6 more authors) (2020) Efficient Approaches for the Synthesis of Diverse α-Diazo Amides. Synthesis, 52 (11). pp. 1695-1706. ISSN 0039-7881
Abstract
Metal-catalysed carbenoid chemistry can be exploited for the synthesis of diverse ranges of small molecules from α-diazo carbonyl compounds. In this paper, three synthetic approaches to α-diazo amides are described, and their scope and limitations are determined. On the basis of these synthetic studies, recommendations are provided to assist the selection of the most appropriate approach for specific classes of product. The availability of practical and efficient syntheses of diverse α-diazo acetamides is expected to facilitate the discovery of many different classes of bioactive small molecules.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020. Thieme. This is an author produced version of a paper published in Synthesis. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | diazo compounds; molecular diversity; carbenoid chemistry |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) The University of Leeds > Faculty of Biological Sciences (Leeds) |
Funding Information: | Funder Grant number EPSRC (Engineering and Physical Sciences Research Council) EP/N025652/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 Jan 2020 16:20 |
Last Modified: | 06 Feb 2021 01:39 |
Status: | Published |
Publisher: | Thieme Publishing |
Identification Number: | 10.1055/s-0039-1690905 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:155857 |