Goldstein, EJC, Citron, DM, Gerding, DN et al. (5 more authors) (2020) Bezlotoxumab for the Prevention of Recurrent Clostridioides difficile Infection: 12-Month Observational Data From the Randomized Phase III Trial, MODIFY II. Clinical Infectious Diseases, 71 (4). ciz1151. pp. 1102-1105. ISSN 1058-4838
Abstract
From Monoclonal Antibodies for C. difficile Therapy II, no participants (n = 0/69) with a sustained clinical cure through 12 weeks following bezlotoxumab infusion experienced recurrent Clostridioides difficile infection (rCDI) after 9 months (versus actoxumab + bezlotoxumab, n = 2/65; versus placebo, n = 1/34). Bezlotoxumab’s efficacy appears to be due to prevention rather than delayed onset of rCDI.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical Infectious Diseases following peer review. The version of record Ellie J C Goldstein, Diane M Citron, Dale N Gerding, Mark H Wilcox, Lori Gabryelski, Alison Pedley, Zhen Zeng, Mary Beth Dorr, Bezlotoxumab for the Prevention of Recurrent Clostridioides difficile Infection: 12-Month Observational Data From the Randomized Phase III Trial, MODIFY II, Clinical Infectious Diseases, , ciz1151, is available online at: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz1151/5689284 https://doi.org/10.1093/cid/ciz1151 |
Keywords: | bezlotoxumab; Clostridioides difficile; recurrence; extension phase |
Dates: |
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Institution: | The University of Leeds |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Jan 2020 10:31 |
Last Modified: | 28 Dec 2020 01:38 |
Status: | Published |
Publisher: | Oxford University Press (OUP) |
Identification Number: | 10.1093/cid/ciz1151 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:155792 |