Brif, A., Laity, P., Claeyssens, F. orcid.org/0000-0002-1030-939X et al. (1 more author) (2020) Dynamic photo-cross-linking of native silk enables macroscale patterning at a microscale resolution. ACS Biomaterials Science & Engineering, 6 (1). pp. 705-714. ISSN 2373-9878
Abstract
Light-based structuring methods have shown reconstituted silk to be a versatile and appropriate material for a range of optical and biomaterial-based applications. However, without an understanding of how an unmodified, native, silk responds to photoprocessing, the full potential of this material cannot be realized. Here, we show that the use of native silk enables the production of compound patterns with improved resolution and image quality when quantitatively compared to standard reconstituted silk, which we link directly to the influence of molecular weight. Further insights into the mechanism behind silk structure development are provided through mechanical (rheological) and structural (FTIR) measurements and results show that processing can tune properties over several orders of magnitude, enabling potential replication of several soft tissue types. Finally, broadening our application perspective, this combination of mask-less lithography and native silk resulted in the fabrication of transparent optical elements for data storage and labeling.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 American Chemical Society. This is an author-produced version of a paper subsequently published in ACS Biomaterials Science and Engineering. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | silk; riboflavin; light; mask-less lithography; micropatterning; rheology |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Materials Science and Engineering (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/K005693/1 ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/I007695/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Jan 2020 12:18 |
Last Modified: | 04 Oct 2020 00:38 |
Status: | Published |
Publisher: | American Chemical Society (ACS) |
Refereed: | Yes |
Identification Number: | 10.1021/acsbiomaterials.9b00993 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:155715 |