Brown, A.W., Holmes, T., Fisher, M. et al. (3 more authors) (2018) Cover feature : Evaluation of sydnone-based analogues of Combretastatin A-4 phosphate (CA4P) as vascular disrupting agents for use in cancer therapy (ChemMedChem 24/2018). ChemMedChem, 13 (24). p. 2600. ISSN 1860-7179
Abstract
This Cover Feature shows a novel sydnone‐based analog of the combretastatins which target and disrupt microtubules, affecting cellular morphology, even at submicromolar concentrations. These compounds offer a new platform for developing hydrophilic, configurationally stable analogs of combretastatins, and a new arsenal of weapons for the fight against cancer.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Wiley‐VCH Verlag. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 22 Jan 2020 10:14 |
Last Modified: | 22 Jan 2020 10:14 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/cmdc.201800768 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:155537 |