Sombra, FM, Richter, AR, de Araújo, AR et al. (8 more authors) (2020) Development of amphotericin B-loaded propionate Sterculia striata polysaccharide nanocarrier. International Journal of Biological Macromolecules, 146. pp. 1133-1141. ISSN 0141-8130
Abstract
This work was aimed at the production and characterization of a new nanocarrier based on a Sterculia striata polysaccharide (SSP) modified via acylation reaction with propionic anhydride. Nanocapsules of propionated SSP (PSSP) were produced via spontaneous nanoemulsification process and tested as a potential amphotericin B (AMB) nanocarrier. Stable nanoparticles with a very low polydispersity index (0.08–0.29) and high zeta potential (ζ −42.7 to −53.8 mV) were obtained. Particle size was dependent on the degree of substitution and ranged from 205 to 286 nm. A nanocapsule with a degree of substitution (DS) of 2.53 (NCP 2.53) was selected for encapsulation, biocompatibility, and antifungal evaluation against Candida albicans strains. A maximum of 98.3% AMB encapsulation was achieved. Encapsulated AMB was in its monomeric form and showed good biocompatibility and antifungal activity against four C. albicans strains. Data indicate that PSSP has potential as a nanocarrier system for AMB.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Sterculia striata polysaccharide; Nanocapsules; Antifungal; Drug delivery |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Jan 2020 12:16 |
Last Modified: | 09 Mar 2020 14:34 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ijbiomac.2019.10.053 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:155199 |