Chambers, J.M. and Prescott, T.J. orcid.org/0000-0003-4927-5390 (2010) Response times for visually guided saccades in persons with Parkinson's disease : a meta-analytic review. Neuropsychologia, 48 (4). pp. 887-899. ISSN 0028-3932
Abstract
Individuals with Parkinson's disease (PD) show marked impairments in their ability to generate self-initiated, or “voluntary”, saccadic eye movements. Investigations of visually guided, or “reflexive”, saccades have, on the other hand, produced inconclusive results with studies showing response times (RTs) in persons with PD that are slower, faster, or indistinguishable from those of controls. We performed a meta-analysis to establish whether there are consistent effects of PD on the metrics of visually guided saccades. Combining results across 47 studies we found that reflexive saccades are overall initiated more slowly in persons with PD than in controls, however, this analysis also revealed considerable heterogeneity across studies. Step-wise meta-regression, using eleven potential predictors, subsequently showed that differences in mean RT between controls and persons with PD may arise due to aspects of experimental design. In particular, mean target eccentricity was shown to impact substantially on RTs such that persons with PD predictably initiate saccades faster than controls at small target eccentricities, while responding more slowly for large target eccentricities. Changes in eye-tracking and display equipment over the period covered by the review were also found to have impacted on the pattern of results obtained. We conclude that a, previously unsuspected, eccentricity effect could explain why the saccadic eye movements of persons with PD are sometimes found to be “hyper-reflexive” compared to controls, and suggest that this effect may arise due to PD-induced changes in both peripheral perceptual processing and in central executive mechanisms involving the basal ganglia.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2009 Elsevier. This is an author produced version of a paper subsequently published in Neuropsychologia. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Parkinson's disease; Saccadic eye movements; Oculomotor function; Basal ganglia; Meta-analysis |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 27 Jan 2020 14:44 |
Last Modified: | 27 Jan 2020 14:44 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.neuropsychologia.2009.11.006 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:155186 |
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Filename: Chambers 2010 Neuropsych Response Times Preprint.pdf
Licence: CC-BY-NC-ND 4.0