Gkotsi, DS, Dhaliwal, J, McLachlan, MMW et al. (2 more authors) (2018) Halogenases: powerful tools for biocatalysis (mechanisms applications and scope). Current Opinion in Chemical Biology, 43. pp. 119-126. ISSN 1367-5931
Abstract
The market sizes for halogenated compounds are huge; in contrast to synthetic chemical alternatives, halogenating enzymes afford the highly regiospecific incorporation of a halogen into an organic molecule, there is therefore great opportunity for the development of industrially relevant halogenases. Here we overview the main classes of halogenases, the mechanisms through which they operate and their structures. We also look at recent applications of halogenases in areas such as metabolite engineering and late stage CH activation. Opportunities and bottlenecks are discussed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Mechanistic Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Dec 2019 09:40 |
Last Modified: | 23 Dec 2019 09:40 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.cbpa.2018.01.002 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:154874 |