Alipourfard, I, Di Renzo, L, De Lorenzo, A et al. (4 more authors) (2019) Single nucleotide polymorphism A-511 G of IL-1 gene modifies anthropometric and physiological parameters of athletes. Meta Gene, 22. 100598. ISSN 2214-5400
Abstract
Interleukin-1β is one of pro-inflammatory responses and plays an important role in cell proliferation, differentiation, and apoptosis. The gene of this cytokine is highly polymorphic, one of which is located on 5´flanking region at position −511 (rs16944, A-511 G). This allele encodes IL-1β protein with less activity in comparison with wild type. In this research, 40 subjects of professional athletes in futsal and volleyball fields have been studied in their anthropometric and physiological indexes and also IL-1β genetic polymorphisms. Our results show that in subjects carrying IL-1β A (−) SNP or wild type allele, the weight, body fat and some other physiological indexes have been increased. This might have relation with elevated plasma level of leptin which is conducted by IL-1β A (−) allele. These findings suggest a remarkable relation between genetic polymorphisms of IL-1β gene and physical potential of athletes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019, Elsevier. All rights reserved. This is an author produced version of an article published in Meta Gene. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Anthropometric; Genotyping; IL-1; Physiological parameters |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Dec 2019 11:16 |
Last Modified: | 29 Jun 2020 00:39 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.mgene.2019.100598 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:154489 |