Wang, Xiaofang, Wei, Zhong, Yang, Keming et al. (5 more authors) (2019) Phage combination therapies for bacterial wilt disease in tomato. Nature Biotechnology. pp. 1513-1520. ISSN 1087-0156
Abstract
Bacteriophage have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage-biocontrol is variable and poorly understood in natural rhizosphere microbiomes at timescales considering both ecological and evolutionary processes. We studied the biocontrol efficacy of different phage combinations on Ralstonia solanacearum infection in tomato. Increasing the number of phages in combinations decreased disease incidence by up to 80% in greenhouse and field experiments during single crop season. Decrease in disease incidence was explained by pathogen density reduction and selection for phage resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic towards Ralstonia solanacearum. Phage treatment did not affect existing rhizosphere microbiota. Specific phage combinations show promise as precision tools to engineer microbiomes and to control plant pathogenic bacteria
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Springer Nature Limited. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 03 Dec 2019 09:30 |
Last Modified: | 21 Dec 2024 00:18 |
Published Version: | https://doi.org/10.1038/s41587-019-0328-3 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1038/s41587-019-0328-3 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:154121 |
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