A quantitative systems pharmacology consortium approach to managing immunogenicity of therapeutic proteins

Abstract

Immunogenicity is a major challenge in drug development and patient care. Currently, most efforts are dedicated to the elimination of the unwanted immune responses through T‐cell epitope prediction and protein engineering. However, because it is unlikely that this approach will lead to complete eradication of immunogenicity, we propose that quantitative systems pharmacology models should be developed to predict and manage immunogenicity. The potential impact of such a mechanistic model‐based approach is precedented by applications of physiologically‐based pharmacokinetics.

Metadata

Item Type:	Article
Authors/Creators:	Kierzek, A.M. Hickling, T.P. https://orcid.org/0000-0002-8918-2140 Figueroa, I. Kalvass, J.C. Nijsen, M. Mohan, K. Veldman, G.M. Yamada, A. Sayama, H. Yokoo, S. Gulati, A. Dhanikula, R.S. Gokemeijer, J. Leil, T.A. Thalhauser, C.J. Giorgi, M. https://orcid.org/0000-0001-7763-8545 Swat, M.J. Chelliah, V. Small, B.G. Benson, N. Walker, M. Gadkar, K. Quarmby, V. Deng, R. Ferrante, A. Dickinson, G.L. Van Der Walt, J.S. Zhou, L. Chen, X. Jones, H.M. Narula, J. Tourdot, S. Lavé, T. Ribba, B. van der Graaf, P.H. https://orcid.org/0000-0003-1314-3484
Copyright, Publisher and Additional Information:	© 2019 The Authors. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Dates:	Accepted: 17 September 2019 Published (online): 8 October 2019 Published: 24 November 2019
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield)
Depositing User:	Symplectic Sheffield
Date Deposited:	03 Dec 2019 10:38
Last Modified:	03 Dec 2019 10:38
Status:	Published
Publisher:	Wiley Open Access
Refereed:	Yes
Identification Number:	10.1002/psp4.12465
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:153749

CORE (COnnecting REpositories)

A quantitative systems pharmacology consortium approach to managing immunogenicity of therapeutic proteins

Abstract

Metadata

Download

Published Version

Export

Statistics