Puppo, M., Taipaleenmäki, H., Hesse, E. et al. (1 more author) (2021) Non‐coding RNAs in bone remodelling and bone metastasis : mechanisms of action and translational relevance. British Journal of Pharmacology, 178 (9). pp. 1936-1954. ISSN 0007-1188
Abstract
Bone metastases are frequent complications in patients with advanced cancer, which can be fatal or may rapidly impede the quality of life of patients. Current treatments for patients with bone metastases are palliative. Therefore, a better understanding of the molecular mechanisms that precede the overt development of skeletal lesions could lead to better therapeutic interventions. In this review, we present evidence that non‐coding RNAs (ncRNAs) such as long non‐coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) are emerging as master regulators of bone metastasis formation. We highlight potential opportunities for the therapeutic targeting of ncRNAs. Furthermore, we discuss the possibility that ncRNAs may be used as biomarkers in the context of bone metastases, which might provide insight for improving the response to current bone‐targeting therapies.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 The British Pharmacological Society. This is an author-produced version of a paper subsequently published in British Journal of Pharmacology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Non-coding RNA; lncRNA; miRNA; circRNA; bone physiology; bone metastasis; biomarkers |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Human Metabolism (Sheffield) The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Oncology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 Nov 2019 12:33 |
Last Modified: | 17 Dec 2021 10:48 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/bph.14836 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:152916 |