Dewulf, J., Vangestel, C., Verhoeven, Y. et al. (4 more authors) (2019) Bone metastases in the era of targeted treatments : insights from molecular biology. The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 63 (2). pp. 98-111. ISSN 1824-4785
Abstract
Bone metastases remain a common feature of advanced cancers and are associated with significant morbidity and mortality. Recent research has identified promising novel treatment targets to improve current treatment strategies for bone metastatic disease. This review summarizes the well-known and recently discovered molecular biology pathways in bone that govern normal physiological remodeling or drive the pathophysiological changes observed when bone metastases are present. In the rapidly changing world of targeted cancer treatments, it is important to recognize the specific treatment effects induced in bone by these agents and the potential impact on common imaging strategies. The osteoclastic targets (bisphosphonates, LGR4, RANKL, mTOR, MET-VEGFR, cathepsin K, Src, Dock 5) and the osteoblastic targets (Wnt and endothelin) are discussed, and the emerging field of osteo-immunity is introduced as potential future therapeutic target. Finally, a summary is provided of available trial data for agents that target these pathways and that have been assessed in patients. The ultimate goal of research into novel pathways and targets involved in the tumor-bone microenvironment is to tackle one of the great remaining unmet needs in oncology, that is finding a cure for bone metastatic disease.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Edizioni Minerva Medica. This is an author-produced version of a paper subsequently published in Quarterly Journal of Nuclear Medicine and Molecular Imaging. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Bone remodeling; Bone and bones; Therapeutics; Physiopathology |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Oncology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 Nov 2019 11:18 |
Last Modified: | 11 Jul 2020 00:39 |
Status: | Published |
Publisher: | Edizioni Minerva Medica |
Refereed: | Yes |
Identification Number: | 10.23736/s1824-4785.19.03203-5 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:152910 |