Frame, Fiona M, Noble, Amanda R, O'Toole, Peter orcid.org/0000-0001-5295-2001 et al. (4 more authors) (2019) Assessing the Advantages, Limitations and Potential of Human Primary Prostate Epithelial Cells as a Pre-clinical Model for Prostate Cancer Research. Advances in experimental medicine and biology. pp. 109-118. ISSN 0065-2598
Abstract
Choosing an appropriate cell model(s) is the first decision to be made before starting a new project or programme of study. Here, we address the rationale that can be behind this decision and we summarize the current cell models that are used to study prostate cancer. Researchers face the challenge of choosing a model that recapitulates the complexity and heterogeneity of prostate cancer. The use of primary prostate epithelial cells cultured from patient tissue is discussed, and the necessity for close clinical-academic collaboration in order to do this is highlighted. Finally, a novel quantitative phase imaging technique is described, along with the potential for cell characterization to not only include gene expression and protein markers but also morphological features, cell behaviour and kinetic activity.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Keywords: | Cell Line,Cell Line, Tumor,Epithelial Cells/cytology,Humans,Male,Prostatic Neoplasms |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) > Yorkshire Cancer Research Unit (York) The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 24 Oct 2019 13:20 |
Last Modified: | 25 Dec 2024 00:20 |
Published Version: | https://doi.org/10.1007/978-3-030-22254-3_9 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1007/978-3-030-22254-3_9 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:152627 |
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