Swan, D., Loughran, N., Makris, M. orcid.org/0000-0001-7622-7939 et al. (1 more author) (2020) Management of bleeding and procedures in patients on antiplatelet therapy. Blood Reviews, 39. 100619. ISSN 0268-960X
Abstract
Antiplatelet medications have long been the mainstay for secondary prevention in cardiovascular disorders. More recently, with the advent of coronary stents, there has been an increased use of more potent antiplatelet agents to prevent stent occlusion. Since these drugs are antithrombotic, it is not unusual for them to be associated with serious bleeding, particularly intracranial and gastrointestinal haemorrhage. There are no robust guidelines on how to manage these clinical situations, although there have been some important studies published recently in this area. Similarly, there is very limited evidence on how to manage urgent surgery in patients receiving these medications. In this review, we provide updated guidance on the management of bleeding and surgery on antiplatelet drugs while stressing the need for further studies to provide evidence-based guidelines.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Elsevier. This is an author produced version of a paper subsequently published in Blood Reviews. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Aspirin; Anaesthesia; Bleeding; Clopidogrel; Antiplatelet; Ticagrelor; Prasugrel; Surgery |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Oct 2019 08:55 |
Last Modified: | 17 Dec 2021 08:45 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.blre.2019.100619 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:152369 |
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