Pérez-Mazliah, Damián orcid.org/0000-0002-2156-2585, Gardner, Peter J, Schweighoffer, Edina et al. (7 more authors) (2018) Plasmodium-specific atypical memory B cells are short-lived activated B cells. eLife. e39800. ISSN 2050-084X
Abstract
A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived memory B cells, and their accumulation may contribute to poor acquisition of long-lasting immunity to certain chronic infections, such as malaria and HIV. Here, we generated an immunoglobulin heavy chain knock-in mouse with a BCR that recognizes MSP1 of the rodent malaria parasite, Plasmodium chabaudi. In combination with a mosquito-initiated P. chabaudi infection, we show that Plasmodium-specific atypical memory B cells are short-lived and disappear upon natural resolution of chronic infection. These cells show features of activation, proliferation, DNA replication, and plasmablasts. Our data demonstrate that Plasmodium-specific atypical memory B cells are not a subset of long-lived memory B cells, but rather short-lived activated cells, and part of a physiologic ongoing B-cell response.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2018, Pérez-Mazliah et al. |
Keywords: | Animals,B-Lymphocyte Subsets/chemistry,B-Lymphocytes/chemistry,Flow Cytometry,Gene Knock-In Techniques,Immunoglobulin G/genetics,Immunologic Memory,Malaria/immunology,Merozoite Surface Protein 1/immunology,Mice, Inbred BALB C,Mice, Inbred C57BL,Plasmodium chabaudi/immunology,Rodent Diseases/immunology |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | Pure (York) |
Date Deposited: | 15 Oct 2019 13:30 |
Last Modified: | 27 Nov 2024 00:36 |
Published Version: | https://doi.org/10.7554/eLife.39800 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.7554/eLife.39800 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:152172 |