Lord, RM and McGowan, PC orcid.org/0000-0002-6155-490X (2019) Organometallic Iridium Arene Compounds: The Effects of C-Donor Ligands on Anticancer Activity. Chemistry Letters, 48 (8). pp. 916-924. ISSN 0366-7022
Abstract
In the past decade, libraries of iridium organometallic arene compounds have expanded rapidly, with the majority of their applications aimed towards effective catalysts and potential anti- cancer drug candidates. Researchers have begun to adapt the traditional “piano-stool” structures to include different bidentate ligands, ancillary ligands and extend the aromaticity and functionality of the arene substituent, all in the hope to optimize their activities and allow the determination of structure activity relationships. Many of the complexes incorporate N- and Odonor ligands, but more recently, these structures have been expanded to include C-donor ligands such as cyclometalated bidentate ligands and N-heterocyclic carbenes. This mini-review highlights the recent and ongoing research in C-donor iridium arene complexes, and discusses their importance as potential anticancer drugs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: |
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Keywords: | Anticancer; Bioinorganic chemistry; Iridium arene complexes |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Inorganic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Oct 2019 11:34 |
Last Modified: | 17 Oct 2019 11:34 |
Status: | Published |
Publisher: | Chemical Society of Japan/Nippon Kagakukai |
Identification Number: | 10.1246/cl.190179 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:152003 |