Khalil, O, Waduud, MA orcid.org/0000-0001-5567-9952, Bailey, MA orcid.org/0000-0001-5038-1970 et al. (2 more authors) (2020) Symptom relief in patients undergoing endovascular management of chronic mesenteric ischaemia. International Angiology, 38 (6). pp. 466-473. ISSN 0392-9590
Abstract
BACKGROUND: Chronic mesenteric ischaemia (CMI) is a rare, but potentially fatal condition, which is becoming increasingly prevalent in elderly patients. This study investigated the impact of endovascular intervention on patient symptomology and the influence of extent of mesenteric disease on patient morbidity and mortality.
METHODS: All patients who underwent primary angioplasty (+/-stenting) to the mesenteric vessels for CMI between July 2008 to July 2017 were retrospectively identified. Patient data relating to co-morbidities, clinical presentation, disease burden, procedural details, symptomatology, re-intervention and mortality were collected. Mortality was assessed using regression analysis, which was adjusted for age and gender.
RESULTS: Overall, 38 patients were included in the study. The median age was 73.5years (interquartile range, 70.0-77.8). Abdominal pain (n = 36), post-prandial pain (n = 32) and weight loss (n = 32) were the most common symptoms reported at presentation. Technical success was achieved in 37 patients. Thirty two patients were symptom free at 6 weeks and 29 patients were symptom free at 2 years. Overall 5 patients required re-intervention. At 30 days and 2 years one and seven patients were deceased, respectively. Significant association was observed between three vessel intervention and overall mortality (adjusted odds ratio 14.5, 95% confidence interval 1.28-165.86, p = 0.031). Majority of patients died of a cause unrelated to their CMI.
CONCLUSIONS: Endovascular intervention for CMI is safe and provides satisfactory short-term and intermediate term symptom resolution in majority of patients. This study supports the routine use of endovascular intervention in the management of this complex disease.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Chronic mesenteric ischaemia; Endovascular; Symptoms; Postprandial pain |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Oct 2019 16:12 |
Last Modified: | 30 Jan 2020 14:31 |
Status: | Published |
Publisher: | Edizioni Minerva Medica |
Identification Number: | 10.23736/S0392-9590.19.04204-4 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:151793 |