Klauck, Felix J.R., James, Michael J. orcid.org/0000-0003-2591-0046 and Glorius, Frank (2017) Deaminative Strategy for the Visible-Light-Mediated Generation of Alkyl Radicals. Angewandte Chemie - International Edition. pp. 12336-12339. ISSN 1433-7851
Abstract
A deaminative strategy for the visible-light-mediated generation of alkyl radicals from redox-activated primary amine precursors is described. Abundant and inexpensive primary amine feedstocks, including amino acids, were converted in a single step into redox-active pyridinium salts and subsequently into alkyl radicals by reaction with an excited-state photocatalyst. The broad synthetic potential of this protocol was demonstrated by the alkylation of a number of heteroarenes under mild conditions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Keywords: | alkyl radicals,amino acids,deamination,photoredox catalysis,redox chemistry |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 01 Oct 2019 13:50 |
Last Modified: | 08 Feb 2025 00:35 |
Published Version: | https://doi.org/10.1002/anie.201706896 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/anie.201706896 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:151508 |