Rutherford, H.A. and Hamilton, N. orcid.org/0000-0002-3299-9133 (2019) Animal models of leukodystrophy : a new perspective for the development of therapies. The FEBS Journal, 286 (21). pp. 4176-4191. ISSN 1742-464X
Abstract
The leukodystrophies are a family of heritable disorders characterised by white matter degeneration, accompanied by variable clinical symptoms including loss of motor function and cognitive decline. Now thought to include over fifty distinct disorders, there are a vast array of mechanisms underlying the pathology of these monogenic conditions and, accordingly, a range of animal models relating to each disorder. While both murine and zebrafish models continue to aid in the development of potential therapies, many of these models fail to truly recapitulate the human condition—thus leaving substantial weaknesses in our understanding of leukodystrophy pathogenesis. Additionally, the heterogeneity in leukodystrophy presentation—both in patients and in vivo models—often results in a narrow focus on single disorders in isolation across much of the literature. Thus, this review aims to synthesise prominent research regarding the most common leukodystrophies in order to provide an overview of key animal models and their utility in developing novel treatments. We begin by discussing the ongoing revolution across the leukodystrophy field following the rise of next generation sequencing, before focusing more extensively on existing animal models from the mouse and zebrafish fields. Finally, we explore how these pre‐clinical models have shaped the development of therapeutic strategies currently in development. We propose future directions for the field and suggest a more critical view of the dogma which has underpinned leukodystrophy research for decades.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Federation of European Biochemical Societies. This is an author-produced version of a paper subsequently published in FEBS Journal. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Leukodystrophy; neuroinflammation; animal models; myelin; X-linked adrenoleukodystrophy; metachromatic leukodystrophy; Krabbe’s disease; AicardiGoutières syndrome; Alexander disease; zebrafish |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection and Immunity (Sheffield) |
Funding Information: | Funder Grant number European Leukodystrophy Association ELA 2016-012F4 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 25 Sep 2019 13:15 |
Last Modified: | 12 Nov 2021 14:16 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/febs.15060 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:151338 |